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New Study Suggests Folate Deficiency Linked with Onset of Dementia

March 13th, 2008

You’re mother was right — it’s never too late to take your vitamins.

It’s well known that not having enough of the B vitamin folate could put an older person at risk for the troubling problems of dementia. But a new study suggests that even people who aren’t officially “deficient” are more likely to develop the disease, which causes anxiety, melancholy, poor memory and loss of bodily functions.

The study, published in the Journal of Neurology, Neurosurgery and Psychiatry, centered on more than 500 South Korean men and women ages 65 years and older. Half of the participants involved in the study lived out in the country, while the other half lived in a city.

Two-and-a-half years after the study began more than eight percent of the people had developed dementia, including nearly seven percent who had Alzheimer’s disease. The researches identified a common characteristic:

The lower a participant’s folate levels, the more likely they were to have dementia.

This could be because the nutrient is essential for keeping new cells fit and working well. In general, Koreans participating in the study had higher folate levels than people in Western countries such as the United States and England; one can infer this is because the local Korean diet includes many leafy greens.  It is important to note the word “folate” is derived from “folium” or “leaf.”).

The study suggests there two simple ways to reduce your risk of dementia:

  1. Eat more folate-rich foods such as fortified breakfast cereals and bread, liver, (3.5) ounces of chicken liver supply nearly twice the minimum daily requirement of folate), eggs, beans, sunflower seeds, asparagus and leafy green vegetables and citrus and melons.
  2. Take a folic acid supplement so that you’re sure to have enough folic acid in your diet.

Folic acid is a synthetic form of folate that is available in many folic acid supplements. Animi-3 is a prescription nutritional supplement that contains 1 mg of folic acid, the amount needed to lower homocysteine, which is thought to be a risk factor for dementia and cardiovascular disease. 

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Barbara S. Levine, R.D., Ph.D., has been a researcher, consultant, and teacher of nutrition at some of the most prestigious medical institutions in the country. Dr. Levine is a DHA & B Vitamin Center scientific advisory board member and director of the first NIH-funded Nutrition Information Center at Memorial Sloan-Kettering Cancer Center, Weill-Cornell Medical College, The Rockefeller University, Hospital for Special Surgery, and Strang Cancer Prevention Center.

Fish versus Fish Oil Capsules: A Comparison

February 13th, 2008

The omega-3 fatty acid content (DHA and EPA) in fish has been found to be of great importance in the prevention and treatment of cardiovascular disease, inflammatory diseases such as arthritis and psychiatric disorders such as depression. For those individuals unable or unwilling to eat the amount of fish necessary to meet the recommended amounts of these essential fatty acids through diet alone, relying on a pharmaceutical grade omega-3 supplement is a viable alternative.    But are all omega-3 supplements created equally? 

 When compared, fish and fish oil capsules have similar effects on the omega-3 fatty acid content of blood cells and plasma phospholipids, according to a study conducted by Dr. William Harris,* Director of the St. Luke’s Lipid and Diabetes Center in Kansas City, Mo., who randomized healthy female volunteers into two groups: 

  • One group of volunteers ate two servings of salmon or albacore tuna per week
  • The other group received a comparable amount of DHA and EPA in an omega-3 capsule each day 

The results of this study yield valuable information especially for those worried about the mercury content and other contaminants in fish.  Be sure to check the ratio of DHA to EPA in omega-3 supplements you purchase. Ideally, choose one that is rich in DHA with a 10:1 ratio of DHA to EPA.    *William S. Harris, James V. Petlala, Scott A. Sands and Philip G. Jones. Comparison of the effects of fish and fish oil capsules on the n-3 content of blood cells and plasma phospholipids. American Journal of Clinical Nutrition, Vol.86, No.6, 1621-1625, December 2007.

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Barbara S. Levine, R.D., Ph.D., has been a researcher, consultant, and teacher of nutrition at some of the most prestigious medical institutions in the country. Dr. Levine is a DHA & B Vitamin Center scientific advisory board member and director of the first NIH-funded Nutrition Information Center at Memorial Sloan-Kettering Cancer Center, Weill-Cornell Medical College, The Rockefeller University, Hospital for Special Surgery, and Strang Cancer Prevention Center.

New Blog on Omega-3s & B Vitamins is Now Live

November 19th, 2007

Nutritional experts  from Weill Cornell Medical College and New York Presbyterian Hospital are pleased to introduce a new weblog dedicated to communicating the clinical importance of essential nutrients in dietary health:

  • DHA
  • EPA
  • Folic Acid
  • Vitamin B6
  • Vitamin B12

The DHA & B Vitamins Center Blog is an online resource and virtual community maintained by leading medical and nutritional authorities on omega-3 fatty acids and B vitamins. The parent Web site, DHAandBvitamins.org, is made possible by an unrestricted educational grant from PBM Pharmaceuticals, Inc., maker of the prescription nutritional supplement Animi-3®.

Please register with our blog and check back frequently for postings on DHA, EPA, folic acid, vitamin B6, and vitamin B12.

We hope this blog will be useful to you in your clinical practice and daily life.  Please register and participate!

 
©2007 PBM Pharmaceuticals